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A glucosamine-dipicolylamine conjugate of 99mTc(I) and 186Re(I) for use in imaging and therapy.

Storr T, Fisher CL, Mikata Y, Yano S, Adam MJ, Orvig C

Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 2A3, Canada.

The synthesis and metal complexation of a glucosamine-appended 2,2'-dipicolylamine ligand to the tricarbonyls of 99mTc and 186Re is described; the ligand was found to bind in a tridentate fashion with the glucosamine function remaining pendant, and the 99mTc complex was found to exhibit exceptional stability towards in vitro ligand exchange experiments.

Published 9 February 2005 in Dalton Trans.
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