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Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells.

Heo HJ, Kim C, Lee HJ, Kim YS, Kang SS, Seo UK, Kim YH, Park YC, Seok JH, Lee CJ

Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Korea.

This study investigated whether carbenoxolone, oleanolic acid and ursolic acid affect ATP-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using (3)H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on (3)H-mucin secretion. The possible cytotoxicity of each agent was investigated with a lactate dehydrogenase assay. The results were as follows: (1) carbenoxolone, oleanolic acid and ursolic acid significantly inhibited the secretion of airway mucin induced by ATP; (2) none of the compounds showed significant cytotoxicity at any concentration. This result suggests that carbenoxolone, oleanolic acid and ursolic acid can regulate 'mucin secretion induced by ATP' - a phenomenon simulating mucus overproduction from inflamed airway epithelial cells - by directly acting on airway mucin-secreting cells. Copyright (c) 2007 John Wiley & Sons, Ltd.

Published 30 January 2007 in Phytother Res.
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